As of March 1, 2026, there were no publicly available stepwise treatment protocols for acute migraine. The American Headache Society (AHS) publishes guidelines for migraine treatment with levels of evidence for each medication but without specific recommendations on a stepwise approach. Published here is the world's 1st publicly available stepwise treatment protocol for acute migraine. This algorithm is based on AHS guidelines and literature on the efficacy and side effects of migraine medications.

If your institution would like to join us in a multicenter study aiming to reduce the length of stay and improve treatment outcomes for acute migraine patients using this treatment protocol, please complete the form located in the Contact page of this website. To download the PDF file, click here.

Keywords: treatment of acute migraine, status migrainosus, resistant migraine, headache, medication overuse headache, treatment protocol, treatment algorithm, neurology